Exercise to Counteract Loss of Bone and Muscle During Androgen Deprivation Therapy in Men with Prostate Cancer

摘要

The original objective was to determine whether a 1-year intensive resistance exercise training (RT) program is more effective than a moderate- intensity walking program in ameliorating the effects on body composition of androgen deprivation therapy (ADT) in men with prostate cancer. It was postulated that: 1) RT will attenuate the declines in bone mineral density (BMD) and fat-free mass (FFM) to a greater extent than walking; and 2) both RT and walking will prevent an increase in fat mass. Primary outcomes are lumbar spine BMD and FFM. Secondary outcomes are: total body and hip BMD; fat mass; markers of bone turnover; serum sex hormones; physical functional performance; quality of life, and risk factors for cardiovascular disease (blood lipids, glucose tolerance, arterial stiffness). Because of the inability to enroll the projected number of participants, the study protocol was modified at the time of the 2006 annual IRB review to focus only on the intensive resistance training intervention.