Use of Exogenous Progestins and Risk or In Situ and Invasive Breast Cancer

摘要

Given the large number of women exposed to progestins through either contraceptives or menopausal hormone therapies, clarifying the etiologic role of progestin in relation to breast cancer is of public health importance. This study s two projects will further our understanding of the potential risk of breast cancer associated with progestin use. Project 1 involves the enrollment of 225 in situ breast cancer cases 20-44 years of age. Project 2 is a case- control study of women 55-74 years of age that will enroll 435 controls and 870 breast cancer cases (with three different histologic types of breast cancer, including 435 ductal cases and 435 lobular and mixed cases). Both projects involve a detailed in-person interview and review and testing of tumor samples for various tumor markers. There are no major findings from this study yet as data collection is currently in progress for both projects.