Studies on Non-H-2 Linked Lymphocyte Activating Determinants. I. Description of the Cell Type Bearing the MLS Product.

摘要

The non-H-2 linked, lymphocyte activating determinants (LADs), which are coded by the minor (histocompatibility) lymphocyte stimulating locus (Mls), were detected on B lymphocytes, but not on immunoglobulin (Ig) negative or on theta positive T lymphocytes. These determinants, like the complement receptor and surface IgD, develop late in neonatal life. Thus, the Mls coded LADs mark a population of B lymphocytes which are not present in the spleens of newborn to 2-week-old mice. Studies of B lymphocytes derived from the spleens of adult mice indicated that the cells that bear the Mls coded LADs have a high density of surface Ig and possess the complement receptor. (Author)