Transrectal Near-Infrared Optical Tomography for Prostate Imaging

摘要

Purpose: to explore the technology of trans-rectal near-infrared (NIR) optical tomography that may benefit accurate, selective prostate biopsy. Updated scope: to develop a TRUS-coupled optical tomography technology for imaging prostate cancer in canine model. Major findings: (1) the onset of a prostate tumor was detected earlier by the researched technique than by using TRUS alone; (2) the changes of blood concentration of a rapidly growing prostate tumor were quantified; (3) the regression of a TVT mass in a canine prostate was detected as having a gradually decreasing oxygen level and a gradually increasing region of reduced oxygenation in the inner area of the tumor foci, coupled with intermittently increased total hemoglobin in the periphery of the mass; (4) a cystic lesion also presented with slightly increased total hemoglobin with oxygen-reduction in the periphery of the lesion, and the slightly increased total hemoglobin was found by histopathology to be related to intralesional hemorrhage. Significance and impact: These discoveries are expected to have impact on more accurate imaging guidance for targeted prostate biopsy, and monitoring treatment of locally advanced disease.