Primary Eye Irritation Potential of Insect Repellents. Methyl N,N'-Dihexylethylenediaminemonocarbamate (CHR4), (E)-1,2,3,4-Tetrahydro-6-Methyl-1-(2-Methyl-1-Oxo-2-Butenyl) Quinoline (CHR5) and 1,2,3,4-Tetrahydro-6-Methyl-1-(3-Methyl-1-Oxo-2-Butenyl) Quinoline (CHR6).

摘要

The insect repellents methyl N,N'-dihexylethlenendiamine-monocarbamate (CHR4), (E)-1,2,3,4-tetrahydro-6-methyl-1-(2-methly-1-oxo-2-butenyl) quinoline (CHR5), and 1,2,3,4-tetrahydro-6-methly-1-(3-methly-1-oxo-2-butenyl) quinoline (CHR6) were tested for ocular irritation potential using Primary Eye Irritation Test on rabbits. The study was conducted in compliance with the Good Laboratory Practice regulations. Of the three repellents tested, only CHR4 was shown to be a positive ocular irritant. CHR4, 0.1 ml undiluted, applied to the eyes of rabbits resulted in readily noticeable corneal opacity, conjunctival redness, and conjunctival chemosis. CHR5 and CHR6 produced irritation of the conjunctiva early in the study, but the level of severity did not meet the criteria for positive eye irritants.