Inhibition of Adenovirus In Vitro DNA Replication by Vesicular Stomatitis Virus Leader RNA.

摘要

The members of the virus family, Rhabdoviridae (from Greek rhabdo = rod), infect large numbers of vertebrates, invertebrates and plants (Wagner et al., 1984). Miny species have been isolated from humans, domestic animals, wildlife, fish, crabs, reptiles and insects. Most members are quite prolific and capable of crossing phylogenetic barriers infecting both plants and insects or insects and animals. This ability led Johnson et al. (1969) to speculate that rhabdoviruses were originally a plant pathogen able to replicate in insects that eventually infected animals. Some well studied members include sigma virus of the fruit fly, spring viremia virus of carp, bovine ephemeral fever virus, vesicular stomatitis virus of cattle, swine and horses, Lagos bat virus and rabies virus which infects all warm blooded animals (Brown and Crick, 1979). These viruses are members of the same family based on the following characteristics. They contain a nonsegmented, anti-message sense, single-stranded RNA genome, which encodes 4-5 genes, possess a lipid envelope and have a bullet or conical shape as determined by electron microscopy. The two major or genera that infect warm blooded an:1mals based on serological interrelatedness are the rabies virus group or lyssaviruses (from Latin lyssa = madness) and the vesicular stomatitis virus group or vesiculoviruses (from Greek vesica = bladder, blister) (Table I). Within lyssaviruses is the virus which produces the dreaded disease, rabies (from old Sanskrit rabhas = to do violence).