REPLICATION TYPE RECOMBINANT NOVEL CORONAVIRUS BASED ON VESICULAR STOMATITIS VIRUS VECTOR, AND PREPARATION METHOD THEREFOR AND APPLICATION THEREOF

摘要

A recombinant novel coronavirus based on a vesicular stomatitis virus vector, and a preparation method therefor and an application thereof. The recombinant novel coronavirus is a virus obtained by replacing a glycoprotein G of a vesicular stomatitis virus with an envelope protein S; the envelope protein S contains an envelope protein S extracellular domain of 2019-nCoV(SARS-CoV-2) or a partial sequence thereof. The recombinant novel coronavirus can simulate the process of invasion of 2019-nCoV(SARS-CoV-2) into cells, can stimulate an organism to produce an immune response against 2019-nCoV(SARS-CoV-2), can be used to study the infection process of 2019-nCoV(SARS-CoV-2), can also be developed into vaccines, and can be used to screen inhibitors for inhibiting virus intrusion, and develop vaccines.