Efficacy of Gamma-glutamylcysteine (GGC) in Ischemia-reperfusion Injury.

摘要

Hemorrhagic shock is a leading cause of death in military combat and civilian trauma (Bellamy, 1984; Lieu, et al., 2004). Better understanding of the associated cellular biochemical changes that occur in ischemia-reperfusion (IR) injury can lead to efficacious therapies (Thomas et al., 2008). Therefore, we have been studying the feasibility of using gamma-glutamylcysteine (GGC) a dipeptide precursor for glutathione as a potential compound in modulating the oxidative stress associated with IR injury.