Chemical Biological Agent and Toxin Detection by Fourier Transform Mass Spectroscopy

摘要

Great sensitivity, resolution, accuracy, and speed have made mass spectrometry (MS) one of the most powerful analytical probes available to date. Among the existing MS techniques, Fourier transform ion cyclotron resonance MS (FT-ICRMS) possesses a number of unparalleled performance features, as does no other physical method that can be integrated in a single instrument. Instead of comparing various MS techniques, this report is dedicated to FT-ICRMS. An overview of FT-ICR is presented, fundamental principles of FT-ICRMS are described, distinctive features are addressed, and specific applications to chemical biological agent and toxin detection are discussed. This report also delineates the scope of the in-house Fourier transform MS project currently in progress. (aw)