Acute Dermal Irritation Study and Salmonella-Escherichia coli/Microsome Plate Incorporation Assay of Hydroprocessed Esters and Fatty Acids (HEFA) Bio- Based Jet Fuels.

摘要

The U.S. Air Force is developing alternative fuels to decrease dependence on foreign oil. All new fuels are potentially hazardous to Air Force personnel and require toxicity evaluation. The objective of the dermal irritation study was to determine the irritative potential of three biobased jet fuels, Hydroprocessed Esters and Fatty Acids-Camelina (HEFA-C), HEFA-Tallow (HEFA-T) and HEFA-Animal Fats and Oils (HEFA-F), and to compare the results with the irritative potential of petroleum based JP-8. Exposures consisted of a single occluded or semi-occluded application to the skin of albino rabbits. Dermal irritation scores for all three HEFA fuels and JP-8 indicated that the fuels were slightly irritating to rabbit skin. One exposure (HEFA-F, semi-occluded) was non-irritating. The Salmonella-Escherichia coli/microsome plate incorporation assay examined two HEFA fuels, HEFA-C and HEFA-T, for mutagenic activity. HEFA-C and HEFA-T were judged to be non-mutagenic under the test conditions used in this study; therefore, the test substances were determined to be negative in the bacterial reverse mutation assay.