Valproic acid intoxication with suicide attempt in a pediatric patient.

摘要

Valproic acid (VPA) is used to manage a variety of conditions, including simple and complex absence seizure disorder, bipolar disorder and migraine prophylaxis. The clinical manifestations of VPA overdose range in severity from mild confusion and lethargy to severe coma and death. The treatment of VPA toxicity is mainly supportive. There is no specific antidote or guidelines for managing VPA intoxication. Hyperammonemia is also associated with VPA both in therapeutic and overdose situations and may contribute to the central nervous system (CNS) toxicity.