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A FUNCTION OF VALPROIC ACID IN SUICIDE GENE THERAPY
A FUNCTION OF VALPROIC ACID IN SUICIDE GENE THERAPY
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机译:戊酸在自杀基因治疗中的作用
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摘要
The present invention relates to a suicide-gene cancer therapy by combining valproic acid (VPA) with stem cells expressing suicide genes such as herpes simplex virus type I thymidine kinase (HSV-TK). Glioma cells and the suicide gene-expressing stem cells treated with the valproic acid are cultured in combination with each other, thereby up-regulating the gap junction and enhancing the bystander effect, leading to an increase in the anticancer effect.
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