Enhancement of antitumor effect of the suicide gene therapy by the combination with cytokine gene therapy

摘要

HSV-TK/GCV system and CD/5FC system aretwo effective systems of cancer suicide gene therapy.We have demonstrated that adenovirus-mediated CD/5FC system could suppress the growth of subcutaneoushuman hepatocellular carcinoma to some degree. Tofurther investigate whether the suicide gene therapyaffects the immune system or the immune systemaffects the effectiveness of suicide gene therapy, acolon adenocarcinoma of BALB/c mice, CT26,