Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain

Koda K.; Hyakkoku K.; Ogawa K.; Takasu K.; Imai S.; Sakurai Y.; Fujita M.; Ono H.; Yamamoto M.; Fukuda I.; Yamane S.; Morita A.; Asaki T.; Kanemasa T.; Sakaguchi G.; Morioka Y.

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Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain

机译：蛋白激酶C对单碘乙酸盐诱发的大鼠关节痛中TRPV1的敏感性

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Objective: To assess the functional changes of Transient receptor potential vanilloid 1 (TRPV1) receptor and to clarify its mechanism in a rat mono-iodoacetate (MIA)-induced joint pain model (MIA rats), which has joint degeneration with cartilage loss similar to osteoarthritis.

机译：目的：评估瞬态受体电位香草酸1（TRPV1）受体的功能变化，并阐明其在大鼠单碘乙酸（MIA）引起的关节疼痛模型（MIA大鼠）中的关节变性并伴有软骨损失的机制，其机理类似于骨关节炎。

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来源
《Osteoarthritis and cartilage》 |2016年第7期|共9页
作者
Koda K.; Hyakkoku K.; Ogawa K.; Takasu K.; Imai S.; Sakurai Y.; Fujita M.; Ono H.; Yamamoto M.; Fukuda I.; Yamane S.; Morita A.; Asaki T.; Kanemasa T.; Sakaguchi G.; Morioka Y.;
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正文语种 eng
中图分类骨科学（运动系疾病、矫形外科学）;
关键词
Mono-iodoacetate; Dorsal root ganglion; TRPV1; Protein kinase C; Joint pain;

机译：碘乙酸盐;背根神经节;TRPV1;蛋白激酶C;关节痛;

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专利

1. Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain [J] . Koda K., Hyakkoku K., Ogawa K., Osteoarthritis and cartilage . 2016,第7期

机译：蛋白激酶C对单碘乙酸盐诱发的大鼠关节痛中TRPV1的敏感性
2. Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Ce- and A-dependent mechanisms in rats and mice [J] . Silvia Amadesi, Graeme S. Cottrell, Lorna Divino, The Journal of Physiology . 2006,第2期

机译：蛋白酶激活受体2通过蛋白激酶Ce和A依赖性机制在大鼠和小鼠中敏化TRPV1
3. Phosphoinositide-3-kinase and mitogen activated protein kinase signaling pathways mediate acute NGF sensitization of TRPV1 [J] . Zhu WG, Oxford GS Molecular and cellular neurosciences . 2007,第4期

机译：磷酸肌醇-3-激酶和丝裂原激活的蛋白激酶信号转导通路介导TRPV1的急性NGF致敏
4. Modulation of TRPV1 by Protein Kinase A [C] . Carla Nau, Michaela Kress International Association for the Study of Pain . 2004

机译：用蛋白激酶A调节TRPV1
5. G Protein-Coupled Receptor Kinase 2 (GRK2) and Toll-like Receptors as Regulators of Central Sensitization in Fibromyalgia and Chronic Temporomandibular Disorders [D] . Angkanawaraphan, Lalilta. 2018

机译：G蛋白偶联受体激酶2（GRK2）和Toll样受体作为纤维肌痛和慢性颞下颌关节疾病中枢敏化的调节剂。
6. A- Kinase Anchoring Protein 150 Controls Protein Kinase C-mediated Phosphorylation and Sensitization of TRPV1 [O] . Nathaniel A. Jeske, Amol M. Patwardhan, Nikita B. Ruparel, -1

机译：A-激酶锚固蛋白150对蛋白激酶C介导的磷酸化和TRPV1的敏化
7. Protease-activated receptor 2 sensitizes TRPV1 by protein kinase Cepsilon- and A-dependent mechanisms in rats and mice [O] . Amadesi Silvia, Cottrell Graeme S., Divino L., 2006

机译：蛋白酶激活受体2通过蛋白激酶Cepsilon和A依赖性机制在大鼠和小鼠中敏化TRPV1

Sensitization of TRPV1 by protein kinase C in rats with mono-iodoacetate-induced joint pain

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