TRPV1 Benzimidazolone based cinnamamide derivatives as TRPV1 antagonists and a pharmaceutical composition for treating or preventing pain containing the same as an active ingredient

摘要

As a TRPV1 ligand, it relates to a benzimidazolone-based cinnamamide derivative and a pharmaceutical composition for the prevention or treatment of pain containing the same as an active ingredient. TRPV1 activation by capsaicin is blocked, but the pH induces an appropriate inhibition of about 20% to 80%, thereby improving pain and effectively reducing side effects such as abnormal body temperature.