TRPV1 Benzimidazolone based cinnamamide derivatives as TRPV1 antagonists and a pharmaceutical composition for treating or preventing pain containing the same as an active ingredient

摘要

As a TRPV1 ligand, it relates to a benzimidazolone-based cinnamamide derivative and a pharmaceutical composition for preventing or treating pain containing the same as an active ingredient. TRPV1 activation by capsaicin is blocked, but the pH induces an appropriate inhibition of about 20% to 80%, thereby improving pain and effectively reducing side effects such as abnormal body temperature.