Comparison of linac based fractionated stereotactic radiotherapy and tomotherapy treatment plans for skull-base tumors.

摘要

BACKGROUND AND PURPOSE: To compare and evaluate helical tomotherapy and linac based fractionated stereotactic radiotherapy (FSRT) techniques in the treatment of skull-base tumors. PATIENTS AND METHODS: Ten patients diagnosed with skull-base tumors, originally planned for optically guided FSRT to prescribed doses of 50.4-54 Gy were replanned for treatment with clinically deliverable helical tomotherapy. All original CT scans, MR-CT fusion defined target and normal structure contours, and PTV margins were used for helical tomotherapy planning. Linac based plans utilized one of the following FSRT planning techniques: non-coplanar or coplanar intensity modulated radiation therapy (IMRT), multiple non-coplanar conformal arcs, and non-coplanar conformal radiation therapy (CRT). These plans were used as the standard to which the subsequent tomotherapy plans were compared, using the following criteria: prescription isodose to target volume (PITV) ratios, an inhomogeneity index (II), equivalent uniform dose (EUD) for PTV volumes, mean normalized total doses (NTDmean) for critical structures, and size of 10, 20, and 30 Gy isodose volumes. RESULTS: Use of both linac based FSRT techniques and helical tomotherapy generated highly conformal treatment plans. Tomotherapy plans, which are predominantly coplanar in nature, compared to non-coplanar linac based plans exhibited increased PITV ratios, variable change in II, similar EUD values, and generally comparable NTD(mean) values for organs at risk. When compared to non-coplanar field arrangements, deliverable (as opposed to idealized) tomotherapy plans also resulted in 13-540% increases in low dose isodose volumes. All criteria except for the II, which was generally improved with tomotherapy, were found to be similar when coplanar linac based plans were compared to helical tomotherapy plans. CONCLUSIONS: Results show a distinct advantage in using non-coplanar beam arrangements for treatment of skull-base tumors. In the case where disease spreads far inferiorly, limiting the ability to use non-coplanar arrangements, helical tomotherapy can be used to generate a comparable treatment plan, with potentially superior homogeneity.