AUGMENTATION BY PHTHALIMTOES OF PHORBOL ESTER-INDUCED EXPRESSION OF TUMOR NECROSIS FACTOR ALPHA MESSAGE

摘要

N(a)-Phthalimidoglutarimide (thalidomide), 2-(2,6-dusopropylphenyl)-li?-iso-indole-l,3-dione (PP-33) and its 4,5,6,7-tetrafluoro derivative (FPP-33) augmented 12-O-tetradecanoylphorbol 13-acetate-induced production by human leukemia HL-60 cells of both tumor necrosis factor alpha (TNF-a) mRNA and secreted TNF-a protein. Intracellular TNF-a protein production was increased to a lesser extent.