Antisense oligonucleotide modulation of tumor necrosis factor-alpha (TNF-alpha) expression
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机译:肿瘤坏死因子-α(TNF-alpha)表达的反义寡核苷酸调节
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摘要
Compositions and methods are provided for inhibiting the expression of human tumor necrosis factor-α (TNF-α). Antisense oligonucleotides targeted to nucleic acids encoding TNF-α are preferred. Methods of using these oligonucleotides for inhibition of TNF-α expression and for treatment of diseases, particularly inflammatory and autoimmune diseases, associated with overexpression of TNF-α are provided.
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