Reducing the burden of ischemia reperfusion: editorial to: 'Effect of Chronic CPT-1 Inhibition on Myocardial Ischemia-Reperfusion Injury (I/R) in a Model of Diet-Induced Obesity' by G. Maarman et al.

摘要

Ischemia reperfiision (I/R) injury relates to the organ damage that results when blood supply is re-instated following an episode is ischemia. This conceptually difficult phenomenon arises from oxidation and inflammation that is triggered by oxidative stress during the period of ischemia after blood flow is restored. Exploration in this field is imperative to better understand the underlying mechanisms of I/R, with the hope of translating these findings to the field of cardiology and cardiac surgery. Much effort is directed at minimising and attempting to reverse the deleterious effects of ischemia that result from coronary artery occlusion, cardiac surgical interventions and cardiopulmonary bypass. Different approaches have been tested to minimize I/R and the most tested and utilised of these is glucose-insulin-potassium (GIK) which has shown benefit outside the realms of poorly controlled diabetes.