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A rare intramedullary spinal cord metastasis from prostate carcinoma

机译:前列腺癌罕见的髓内脊髓转移

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Sir,A 74-year-old man presented with a 2-week history of decreased sensation and weakness of bilateral lower extremities along with urinary incontinence. Neurologic examination showed decreased sensation from the lumbar one dermatome below. Thoracic magnetic resonance imaging (MRI) revealed a solitary intramedullary lesion located at thoracic 12 levels with homogeneous contrast enhancement [Figure la, c and e]. With the aid of intraoperative neuromonitoring, the tumor was resected radically after dorsal midline myelotomy and post-operative thoracic MRI demonstrated total resection of intramedullary spinal cord tumor [Figure lb, d and fj. Histopathological examination with hematoxylin and eosin revealed a malignant tumor consisting of nests of cells with abundant cytoplasm and prominent mitoses [Figure 2a]. Immunochemistry examination further showed prostatic specific acid phosphatase was positive [Figure 2b], which indicated the diagnosis of metastatic prostate adenocarcinoma. A needle aspiration biopsy of the prostate confirmed the diagnosis of prostate carcinoma and systemic bone scan showed numerous sites of metastases involved pelvis, thigh bones and vertebrae [Figure 3]. Post-operative period was uneventful and patient remained at his baseline neurological status except improved sensation. After receiving hormonal therapy, he remained neurologically stable for 6 months.
机译:主席先生,一位74岁的男性患者有2周的双下肢感觉减退和无力以及尿失禁的病史。神经系统检查显示腰部以下一个皮肤刀的感觉降低。胸腔磁共振成像(MRI)显示位于胸部12级的单个髓内病变,并具有均一的对比增强效果[图1a,c和e]。借助术中神经监测,在背侧中线骨髓切开术后彻底切除了肿瘤,并且术后胸部MRI证实了髓内脊髓肿瘤的全部切除[图1b,d和fj。用苏木精和曙红进行的组织病理学检查显示为恶性肿瘤,由具有丰富细胞质和突出有丝分裂的细胞巢组成[图2a]。免疫化学检查进一步显示前列腺特异性酸性磷酸酶为阳性[图2b],这表明对转移性前列腺腺癌的诊断。前列腺穿刺活检证实了前列腺癌的诊断,全身骨扫描显示许多转移部位涉及骨盆,大腿骨和椎骨[图3]。术后期间平稳,除感觉改善外,患者保持其基线神经系统状态。接受激素治疗后,他在神经学上保持稳定6个月。

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