Analysis of Fluoroquinolone Antibiotics in Foods

摘要

Residual fluoroquinolone levels in animal foods retailed in Korea were monitored according to the method outlined in Korea Food Code using HPLC-FLD and HPLC-ESI-MS/MS for confirmation. The optimum ion transitions were 360->316, 342 m/z for enrofloxacin, 332->314, 288 m/z for ciprofloxacin, 320->301, 230 m/z for norfloxacin, 334->315, 290 m/z for pefloxacin, 362->318, 261, 334 m/z for ofloxacin, and 262->201, 126 m/z for flumequin. Enrofloxacin, ciprofloxacin and norfloxacin residues were found in 12out of 388 samples. These antibiotics were only found in chicken samples, while no residues were found in beef, pork, milk and egg samples. Using this monitoring method, detection rates of 3.1, 1.3, and 0.3% were obtained for enrofloxacin, ciprofloxacinand norfloxacin, respectively. The levels of enrofloxacin, ciprofloxacin and norfloxacin detected in food samples ranged from 0.01 to 0.73 mg/kg in 12 samples, 0.01-0.03 mg/kg in 5 samples, and 0.12 mg/kg in only a sample, respectively.