The anti-inflammatory properties of chloroform, methanol and aqueous extracts of the leaves of Salvia connivens Epling were investigated. It was found that aqueous extract on carraggenan induced edema at dose of 400 mg/kg had no activity. Methanol extract at the same dose inhibited the edema 64.3 ± 18% (1 h), however the effect decreased after this time. Chloroform extract showed at this dose an inhibition of 73.8 ± 10.6% (4 h), and the effect observed for this extract at dose of 200 mg/kg was 87.76 ± 7.6% (5 h). Indomethacin was used as a positive control and inhibited edema by 73.2 ± 3.5% at a dose of 8 mg/kg. Tests demonstrated that the chloroform extract inhibited 12-O-tetradecanoyl-phorbol-13-acetate (TPA)-induced ear edema in mouse by 50.7± 2.1%; The chloroform extract inhibited pellet implantation-induced granuloma formation by 39.34 ± 5.36% at a dose of 200 mg/kg, a result comparable to that exhibited by naproxen at a dose of 50 mg/kg (40.81 ± 4.78%). These results suggest that S. connivens chloroform extract has anti-inflammatory activity, supporting its folkloric use for treatment of inflammatory diseases.
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