Naphthofuroquinone Derivatives: DNA Topoisomerase-I Inhibition and Cytotoxicity

摘要

The naphthoquinone skeleton is found in many natural products and has been employed as a synthetic intermediate for the preparation of numerous heterocyclic compounds with interesting biological properties such as antitumor,antibacterial,antifungal and antiinflammatory agents.The quinone core of streptonigrin and lavendamycin has been proposed to be a determining factor in their antitumor activity.Recently,the linearly substituted quinolinediones have revealed the importance of the quinone framework for potent antitumor activity against the cell lines.