Synthesis of Styrylquinoline Carboxamides for HIV-1 Integrase Inhibitors

摘要

AIDS is essentially a viral disease and should be treated by antiretroviral agents.From this standpoint,HIV DNA integration into genomic DNA of the host cell,a crucial step in the life cycle of the virus,constitutes a particularly attractive target for AIDS chemotherapeutics,including potential synergy with currently available HIV reverse transcriptase and protease inhibitors.