首页> 外国专利> N-BENZYL-3,4-DIHYROXYPYRIDINE-2-CARBOXAMIDE AND N-BENZYL-2,3-DIHYDROXYPYRIDINE-4-CARBOXAMIDE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS

N-BENZYL-3,4-DIHYROXYPYRIDINE-2-CARBOXAMIDE AND N-BENZYL-2,3-DIHYDROXYPYRIDINE-4-CARBOXAMIDE COMPOUNDS USEFUL AS HIV INTEGRASE INHIBITORS

机译:N-苄基-3,4-二羟吡啶-2-羧酰胺和N-苄基-2,3-二氧吡啶-4-羧酰胺化合物可用作HIV整合酶抑制剂

摘要

N-Benzyl-dihydroxypyridine carboxamide compounds are inhibitors of HIV integrase and inhibitors of HIV replication. In one embodiment, the dihydroxypyridine carboxamides are of Formula (I) wherein Q is Formula (II) or Formula (III); T is Formula (IV); and R1, R2, X',X2,X3, and Y1 are defined herein. The compounds are useful in the prevention and treatment of infection by HIV and in the prevention, delay in the onset, and treatment of AIDS. The compounds are employed against HIV infection and AIDS as compounds per se or in the form of pharmaceutically acceptable salts. The compounds and their salts can be employed as ingredients in pharmaceutical compositions, optionally in combination with other antivirals, immunomodulators, antibiotics or vaccines.
机译:N-苄基-二羟基吡啶羧酰胺化合物是HIV整合酶的抑制剂和HIV复制的抑制剂。在一个实施方案中,二羟基吡啶羧酰胺具有式(I),其中Q是式(II)或式(III); T是式(IV);在此定义R1,R2,X',X2,X3和Y1。所述化合物可用于预防和治疗HIV感染以及预防,延缓发病和治疗AIDS。该化合物本身或以药学上可接受的盐的形式用于对抗HIV感染和AIDS。所述化合物及其盐可用作药物组合物中的成分,任选地与其他抗病毒剂,免疫调节剂,抗生素或疫苗组合。

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