Characterization of the mechanism of action of allosteric inhibitors for HIV Integrase using HDX Mass Spectrometry

机译：使用HDX质谱法对HIV整合酶进行颠覆抑制剂作用机理的特征

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ALLINIs induce aberrant IN multimerization through the C-terminal domain. Wild-type IN is susceptible to ALLINI (BI-B2) induced aberrant multimerization while the resistant mutant A128T and CTD mutants K264A/K266A form ordered tetramers.

机译：Allinis通过C末端域诱导多元化的异常。野生型易受Allini（Bi-B2）诱导的异常多聚化的影响，而抗性突变体A128T和CTD突变体K264A / K266A形式有序四聚体。

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《ASMS Conference on Mass Spectrometry and Allied Topics》|2015年||共1页
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Venkatasubramanian Dharmarajan; Nikoloz Shikriabai; Lei Feng; Matthew R. Plumb; Mamuka Kvaratskhelia; Patrick R. Griffin;
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1. Multimode, Cooperative Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors [J] . Jacques Kessl, Nivedita Jena, Yasuhiro Koh, The Journal of biological chemistry . 2012,第20期

机译：颠覆性HIV-1整合酶抑制剂的多模，合作机制
2. The mechanism of H171T resistance reveals the importance of N_δ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase [J] . Alison Slaughter, Kellie A Jurado, Nanjie Deng, Retrovirology . 2014,第S1期

机译：H171T抗性的机制揭示了N _{δ质子化的His171对于变构抑制剂BI-D与HIV-1整合酶结合的重要性}
3. An allosteric mechanism for inhibiting HIV-1 integrase with a small molecule. [J] . Kessl JJ, Eidahl JO, Shkriabai N Molecular pharmacology. . 2009,第4期

机译：一种抑制HIV-1与小分子整合的变构机制。
4. Characterization of the mechanism of action of allosteric inhibitors for HIV Integrase using HDX Mass Spectrometry [C] . Venkatasubramanian Dharmarajan, Nikoloz Shikriabai, Lei Feng, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：使用HDX质谱法对HIV整合酶进行颠覆抑制剂作用机理的特征
5. Mechanistic and Structural Investigations into the Mode of Action of Allosteric HIV-1 Integrase Inhibitors [D] . Koneru, Pratibha Chowdary. 2019

机译：机械和结构研究进入颠覆性HIV-1整合酶抑制剂的作用方式
6. The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors [O] . Lei Feng, Amit Sharma, Alison Slaughter, 2013

机译：A128T抗性突变揭示了异常的蛋白质多聚化为变构HIV-1整合酶抑制剂的主要作用机理。
7. The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors [O] . Lei Feng, Amit Sharma, Alison Slaughter, 2013

机译：A128T抗性突变显示出异常蛋白质多聚化作为颠覆性HIV-1整合酶抑制剂的主要作用机制

Characterization of the mechanism of action of allosteric inhibitors for HIV Integrase using HDX Mass Spectrometry

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