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The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

机译：A128T抗性突变显示出异常蛋白质多聚化作为颠覆性HIV-1整合酶抑制剂的主要作用机制

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Lei Feng; Amit Sharma; Alison Slaughter; Nivedita Jena; Yasuhiro Koh; Nikolozi Shkriabai; Ross C. Larue; Pratiq A. Patel; Hiroaki Mitsuya; Jacques J. Kessl; Alan Engelman; James R. Fuchs; Mamuka Kvaratskhelia;
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1. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies [J] . Deng Nanjie, Hoyte Ashley, Mansour Yara E., Protein Science: A Publication of the Protein Society . 2016,第11期

机译：变构HIV-1整合酶抑制剂通过直接介导亚基间相互作用促进异常的蛋白质多聚化：结构和热力学模型研究
2. Allosteric HIV-1 integrase inhibitors promote aberrant protein multimerization by directly mediating inter-subunit interactions: Structural and thermodynamic modeling studies [J] . Deng Nanjie, Hoyte Ashley, Mansour Yara E., Protein Science: A Publication of the Protein Society . 2016,第11期

机译：颠覆HIV-1整合酶抑制剂通过直接调解亚基间相互作用来促进异常蛋白质多聚化：结构和热力学建模研究
3. The mechanism of H171T resistance reveals the importance of N_δ-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase [J] . Alison Slaughter, Kellie A Jurado, Nanjie Deng, Retrovirology . 2014,第S1期

机译：H171T抗性的机制揭示了N _{δ质子化的His171对于变构抑制剂BI-D与HIV-1整合酶结合的重要性}
4. Characterization of the mechanism of action of allosteric inhibitors for HIV Integrase using HDX Mass Spectrometry [C] . Venkatasubramanian Dharmarajan, Nikoloz Shikriabai, Lei Feng, ASMS Conference on Mass Spectrometry and Allied Topics . 2015

机译：使用HDX质谱法对HIV整合酶进行颠覆抑制剂作用机理的特征
5. Mechanistic and Structural Investigations into the Mode of Action of Allosteric HIV-1 Integrase Inhibitors [D] . Koneru, Pratibha Chowdary. 2019

机译：机械和结构研究进入颠覆性HIV-1整合酶抑制剂的作用方式
6. The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors [O] . Lei Feng, Amit Sharma, Alison Slaughter, 2013

机译：A128T抗性突变揭示了异常的蛋白质多聚化为变构HIV-1整合酶抑制剂的主要作用机理。
7. The mechanism of H171T resistance reveals the importance of N-protonated His171 for the binding of allosteric inhibitor BI-D to HIV-1 integrase [O] . 2014

机译：H171T抵抗的机制揭示了N质子化的His171对于变构抑制剂BI-D与HIV-1整合酶结合的重要性

The A128T Resistance Mutation Reveals Aberrant Protein Multimerization as the Primary Mechanism of Action of Allosteric HIV-1 Integrase Inhibitors

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