Leiomyosarcoma is a malignant entity that commonly affects the soft tissues of the body, such as the uterus, gastrointestinal system, and the soft tissues of the extremities. Primary leiomyosarcoma of the bone is a very rare tumor that affects the metaphysis of long bones, especially the distal femur and proximal tibia. Leiomyosarcoma has a radiologic aggressive pattern. The diagnosis is based on microscopic features (elongate and spindled tumor cells) and immumohistochemical and ultrastructural study.
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