Ongoing gleason grade migration in localized prostate cancer and implications for use of active surveillance

摘要

Active surveillance (AS), the ongoing reassessment of low-risk cancer with delayed treatment if clinically indicated, is a management strategy intended to minimize unnecessary treatment of localized prostate cancer (PCa) without compromising mortality rates [1]. Given increasing enthusiasm for AS, our objective was to analyze temporal trends in US men with localized PCa meeting standard low-risk criteria.All men diagnosed with nonmetastatic PCa and known information on prostate-specific antigen (PSA), clinical stage, and Gleason score were identified using data from Surveillance Epidemiology and End Results (SEER; 2004-2010, n = 310 875) and the National Cancer Data Base (NCDB; 2004-2011, n = 640 996) [2,3].