Bioinformatics-based design of novel antigenic B-cell linear epitopes of Deinagkistrodon acutus venom

Cao Y. -L; Guo G. -N.; Zhu G. -Y.; Tian Z.; Gou Y. -J.; Chen C.; Liu M. -H.

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Bioinformatics-based design of novel antigenic B-cell linear epitopes of Deinagkistrodon acutus venom

机译：基于生物信息学的尖吻蛇毒新抗原B细胞线性表位的设计

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摘要

OBJECTIVE: With the help of bioinformatics analysis, we wished to develop a novel antivenom against the Deinagkistrodon (D.) acutus snake venom using B-cell linear epitopes of three primary toxins (serine protease, metalloprotease, and phospholipase A2).

机译：目的：借助生物信息学分析，我们希望使用三种主要毒素（丝氨酸蛋白酶，金属蛋白酶和磷脂酶A2）的B细胞线性表位，开发一种针对Deinagkistrodon（D.）acutus蛇毒的新型抗蛇毒血清。

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《European review for medical and pharmacological sciences.》 |2016年第4期|共7页
作者
Cao Y. -L; Guo G. -N.; Zhu G. -Y.; Tian Z.; Gou Y. -J.; Chen C.; Liu M. -H.;
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正文语种 eng
中图分类药理学;
关键词
Deinagkistrodon acutus; Snake venoms; B-cell linear epitopes; Bioinformatics;

机译：cut蛇;蛇毒;B细胞线性表位;生物信息学;

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专利

1. Bioinformatics-based design of novel antigenic B-cell linear epitopes of Deinagkistrodon acutus venom [J] . Cao Y. -L, Guo G. -N., Zhu G. -Y., European review for medical and pharmacological sciences. . 2016,第4期

机译：基于生物信息学的尖吻蛇毒新抗原B细胞线性表位的设计
2. B-cell linear epitopes mapping of antigen-5 allergen from Polybia paulista wasp venom [J] . Aparecido dos Santos-Pinto Jose Roberto, dos Santos Lucilene Delazari, Arcuri Helen Andrade, The Journal of Allergy and Clinical Immunology . 2015,第1期

机译：Poly虫蜂黄蜂毒液抗原5过敏原的B细胞线性表位定位
3. Identification of a linear B-cell epitope in the catalytic domain of bothropasin, a metalloproteinase from Bothrops jararaca snake venom [J] . Molina Molina Denis A., Guerra-Duarte Clara, Naves de Souza Dayane L., Molecular Immunology . 2018,第期

机译：鉴定兼吡泮催化结构域的线性B细胞表位，来自Bothrops Jararaca Snake Venom的金属蛋白酶
4. Identification and Characterization of a Thrombin-like enzyme isolated from Deinagkistrodon acutus venom [C] . Yu Xi, Dexian Dong, Rongxiu Li International Conference on Separation Science and Technology(ICSST'2007); 20071014-16; Beijing(CN) . 2007

机译：从尖吻De蛇毒中分离出的凝血酶样酶的鉴定与表征
5. Identification of B-cell epitopes on domain 4 of anthrax protective antigen. [D] . Kelly-Cirino, Cassandra D. 2009

机译：鉴定炭疽保护性抗原第4结构域上的B细胞表位。
6. Linear B-cell epitopes in BthTX-I BthTX-II and BthA-I phospholipase A2s from Bothrops jararacussu snake venom recognized by therapeutically neutralizing commercial horse antivenom [O] . Salvatore De-Simone, Paloma Napoleão-Pêgo 2014

机译：BthTX-IBthTX-II和BthA-I中的线性B细胞表位来自Bothrops jararacussu蛇毒的磷脂酶A2通过治疗中和商业化的马抗蛇毒血清被识别
7. Table 2: B-cell epitopes predicted using Bepipred linear epitope prediction 2.0 in IEDB analysis resource web-server along with their start and end positions, average score, and VaxiJen 2.0 determined antigenicity scores. [O] . -1

机译：表2：使用IEDB分析资源Web-Server中的Bepipipe线性表位预测2.0预测的B细胞表位以及其开始和结束位置，平均分数和Vaxijen 2.0确定的抗原性分数。
8. Human Linear B-Cell Epitopes Encoded by the Hepatitis E Virus IncludeDeterminants in the RNA-Dependent RNA Polymerase [R] . Kaur, M., Hyams, K. C., Purdy, M. A., 1992

机译：由戊型肝炎病毒编码的人类线性B细胞表位包括RNa依赖性RNa聚合酶中的决定因子

Bioinformatics-based design of novel antigenic B-cell linear epitopes of Deinagkistrodon acutus venom

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