Establishing the correlation between statins and-eough:case series report and analysis of adverse drug reactions in the international databases

摘要

Statins are generally well tolerated, even if muscle tox-icity and interstitial lung disease (ILD) may occur [1, 2], The association of cough with statins in the absence of lung injury has been reported only twice in the literature [3. 4]. To define better this association, we carried out an analysis from 2004 to 2012 using the Australian database of Adverse Event Notifications (DAEN), the Canada Vigilance Adverse Reaction Online Database and the United States Food and Drug Administration Adverse Event Reporting System (AERS) databases. We considered reports where statin was the only suspected drug for cough; suspected reports of 'cough' were detected using the Medical Dictionary for Regulatory Activities code (MedDRA) at the Preferred Term (PT) level [5].