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Pharmaceutical Composition for Preventing or Treating Adverse Drug Reactions by Statin

机译:抑制素预防或治疗药物不良反应的药物组合物

摘要

The present disclosure relates to a pharmaceutical composition for preventing or treating statin-induced adverse effects or a pharmaceutical composition for co-administration with statin, the pharmaceutical composition containing, as an active ingredient, at least one selected from the group consisting of an isoprenoid-based compound, zaragozic acid, terbinafine, and ketoconazole. The pharmaceutical composition according to the present disclosure may prevent and/or treat adverse statin effects that can be induced by statin, that is, can be induced at any time by oxisterols present at abnormal levels in the body. The pharmaceutical composition can not only treat but also prevent the adverse effects of various statin therapeutics whose use has recently increased rapidly, and thus it is expected that the pharmaceutical composition can be widely used for various diseases and the utilization thereof can further be increased.
机译:本公开涉及一种用于预防或治疗他汀类药物引起的不良反应的药物组合物或用于与他汀类药物共同给药的药物组合物,该药物组合物包含至少一种选自类异戊二烯-的化合物作为活性成分。基化合物,扎拉果酸,特比萘芬和酮康唑。根据本公开的药物组合物可以预防和/或治疗他汀类药物可以诱导的不利的他汀类药物作用,也就是说,可以在任何时间通过以体内异常水平存在的氧杂环丁醇诱导。该药物组合物不仅可以治疗而且还可以防止最近使用量迅速增加的各种他汀类药物治疗剂的不良作用,因此期望该药物组合物可以广泛用于各种疾病,并且可以进一步提高其利用率。

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