Efficacy of and risk of bleeding during pegylated interferon plus ribavirin treatment in HIV/HCV-coinfected patients with pretreatment thrombocytopenia

摘要

The aim of this study was to assess the efficacy of and the risk of major bleeding during pegylated interferon (peg-IFN)/ribavirin (RBV) treatment among human immunodeficiency virus (HIV)/hepatitis C virus (HCV)-coinfected patients according to the pretreatment platelet count. Two hundred and seventy-four HCV/HIV-coinfected, previously na < ve individuals with compensated cirrhosis enrolled in one Spanish prospective cohort who received peg-IFN/RBV were included in this study. The frequency of severe bleeding and sustained virological response (SVR) rate were compared between patients with a pretreatment platelet count a parts per thousand currency sign70,000/mm(3) and > 70,000/mm(3), respectively. Sixty-one (22 %) patients had a baseline platelet count a parts per thousand currency sign70,000/mm(3). The median (Q1-Q3) pretreatment platelet count was 58,000 (49,000-65,000) cells/mm(3) in the platelet a parts per thousand currency sign70,000 group and 129,000 (102,500-166,000) cells/mm(3) in the platelet > 70,000 group (p < 0.0001). Seventeen (28 %) subjects of the platelet a parts per thousand currency sign70,000 group and 71 (33 %) patients of the platelet > 70,000 group achieved SVR (p = 0.4). Only 2 (3.2 %) patients in the platelet a parts per thousand currency sign70,000 group developed a severe hemorrhagic event, specifically esophageal variceal bleeding. The efficacy of therapy with peg-IFN/RBV in HIV/HCV-coinfected patients with low pretreatment platelet counts is comparable to that found in the overall subset of subjects with compensated cirrhosis. The frequency of severe hemorrhagic events related with this therapy is low in this population.