Secretory endometrial intraepithelial Neoplasia

摘要

Recognition of preneoplastic endometrial lesions with secretory features can be vexing and is an emerging topic of discussion in the literature. We read with great interest the article entitled "Hyperplasia and carcinoma in secretory endometrium: a diagnostic challenge" by Drs Truskinovsky, Lifschitz-Mercer, and Czernobilsky published in the March 2014 issue of your journal (volume 33(2), pp. 107-113) (1). In their study of 80 cases of endometrial hyperplasia, carcinoma, and other conditions with glandular crowding arising in a secretory endometrium, the features that best distinguished hyperplasia and carcinoma from secretory endometrium were glandular crowding distinct from the background, architectural disorder, cytologic atypia, fibrotic stroma, and cribri-forming/confluent gland growth in cases of carcinoma. In addition, the authors state that "the nuclear features of the suspicious areas should be compared with those of the non-neoplastic endometrium in the background." These conclusions essentially summarize the criteria set forth for the diagnosis of endometrial intraepithelial neoplasia (EIN).