ACYCLIC NUCLEOSIDE PHOSPHONATE DIESTERS FOR USE IN TREATING HUMAN PAPILLOMA VIRUS, CERVICAL INTRAEPITHELIAL NEOPLASIA, ANAL INTRAEPITHELIAL NEOPLASIA, OR VULVAR INTRAEPITHELIAL NEOPLASIA

摘要

The present disclosure relates, inter alia, to a compound of Formula (la):or a pharmaceutically acceptable salt thereof for use in treating human papilloma virus, cervical intraepithelial neoplasia, anal intraepithelial neoplasia, or vulvar intraepithelial neoplasia to a subject in need thereof wherein:B_Nuc(_a) is selected from the group consisting of:L^a is an unsubstituted C_13-29 heteroalkyl;R^a is selected from the group consisting of an unsubstituted C_1-6 alkyl, a substituted or unsubstituted aryl, a substituted or unsubstituted heteroaryl, a substituted or unsubstituted heterocycloalkyl, a substituted or unsubstituted aryl(C_1-6 alkyl), a substituted or unsubstituted heteroaryl(C_1-6 alkyl) and a substituted or unsubstituted heterocycloalkyl(C_1-6alkyl);X^a is hydrogen, an unsubstituted C_1-6alkyl, a halogen substituted C_1-6alkyl, a hydroxy substituted C_1-6 alkyl or an unsubstituted C_1-6 alkoxy;wherein alkyl is fully saturated; andwherein the substituent is selected from the following moieties: -OH, -NH₂, -SH, -CN, -CF₃, -NO₂, oxo, halogen, unsubstituted alkyl, unsubstituted heteroalkyl, unsubstituted cycloalkyl, unsubstituted heterocycloalkyl, unsubstituted aryl, and unsubstituted heteroaryl.