Down‐regulated nucleoside diphosphate kinase nm23‐H1 expression is unrelated to high‐risk human papillomavirus but associated with progression of cervical intraepithelial neoplasia and unfavourable prognosis in cervical cancer

摘要

ObjectiveOne of the factors leading to an invasive phenotype is the nm23 family of metastases‐associated genes. Of the six known members, nm23‐H1 is the most frequently studied potential anti‐metastatic gene in cervical cancer. However, the possible molecular links to oncogenic human papillomavirus (HPV) are completely unexplored as yet.