Risk of subsequent endometrial carcinoma associated with Endometrial Intraepithelial Neoplasia (EIN) classification of endometrial biopsies

摘要

BackgroundHistopathologic diagnosis of endometrial biopsies is used to estimate the risk of progression to carcinoma and guide clinical management. Problems with the widely used World Health Organization (WHO) system for classifying endometrial hyperplasia (EH) have prompted the development of an alternative system based on Endometrial Intraepithelial Neoplasia (EIN). We estimated progression risk associated with EIN among endometrial biopsies in a nested case-control study of EH progression.