Anti Anxiety Effect of Ghavoot: A Traditional Nutrient Preparation

摘要

Ghavoot is an Iranian preparation composed of a combination of different plant seeds which has been prepared in a specific manipulation. This drug has different traditional uses which has never been studied scientifically. In the present study, the anti anxiety effect of Ghavoot has been studied in mice using Elevated Zero Maze (EZM) method. The animals received the Ghavoot at doses of 12, 18 and 24 g kg~(-1) orally for 14 days. The anxiolytic effect of test groups was compared to diazepam on the basis of animal behaviors on 15th day of experiment. The time spent in the open arms, number of open arm entries, number of animal stretching, line crossing and deep heading of animal on open edges were measured for 5 min. All of the experiment were done atthe time of 9-13 a.m. The results showed that Ghavoot significantly (p<0.05) elevated the time spent on the open arms and open arm entries at dose of 24 g kg~(-1) in comparison to control group, without significant changes in the other parameters. The results here provide scientific evidence that Ghavoot has potential anti anxiety effect in mice.