DESIGN AND EVALUATION OF RECONSTITUTABLE ORAL SUSPENSION CONTAINING DELAYED RELEASE PANTOPRAZOLE MICROSPHERES

摘要

The aim of the min present study was to develop pantoprazole suspension containing delayed release (DR) microspheres to target the drug release intestine. This study is divided into two sections, first one is to prepare DR pantoprazole microspheres and second is to formulate into reconstitutional oral suspension. Quality by Design (QbD) approach was used in the study. Polymethacrylate (Eudragit L100-55) was used for the development of delayed release microspheres. To prepare reconstitutional suspension formulation, 90% particle size of microspheres less than 50 microns and with 90% loading efficiency was used. Xanthan gum is used as suspending agent and D-mannitol is used as sweetening agent. FTIR study shows compatibility of the drug with polymer. Moreover, the same release rate of pantoprazole from the suspension and microspheres alone indicated that the suspension medium studied did not affect the property of drug release during storage.