首页> 外文期刊>American Journal of Hypertension >Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome.
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Angiotensin II type 1 receptor gene polymorphism predicts development of hypertension and metabolic syndrome.

机译:血管紧张素II 1型受体基因多态性预测高血压和代谢综合征的发展。

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BACKGROUND: The aim of the study was to investigate the effect of polymorphism A1166C for AGTR1 and -1332G/A for AGTR2 on the incidence of sustained hypertension (HT) and metabolic syndrome in a cohort of young patients screened for stage 1 HT. METHODS: We assessed 420 white hypertensive subjects never treated for HT and followed up for 7.3 years in the HT and Ambulatory Recording Venetia Study (HARVEST). Incident physician-diagnosed HT, increase in ambulatory blood pressure (BP), and new onset metabolic syndrome were the outcome measures. RESULTS: For AGTR1, 37.2% of the subjects in the group with AA genotype, 47.5% in the group with AC genotype, and 66.7% in the group with CC genotype developed HT during follow-up (P = 0.001). Ambulatory systolic (P = 0.007) and diastolic (P < 0.001) BPs increased largely in the patients with CC genotype than in the rest of the group. New onset metabolic syndrome during follow-up (n = 30, P = 0.008), and the frequency of the metabolic syndrome at the end of follow-up(n = 65, P = 0.002) were also more common among the patients with CC and AC genotype. In a Cox analysis, subjects with CC genotype had an increased risk of developing HT (hazard ratio (HR) 1.6, 95% confidence interval (CI) 1.2-2.0, P = 0.000) and metabolic syndrome (HR 2.8, 1.5-5.2, P = 0.002) than AA subjects. No association was found between the AGTR2 polymorphism and any outcome measure. CONCLUSIONS: The AGTR1 A1166C polymorphism may be considered a genetic marker predisposing to an increase in BP and the development of the metabolic syndrome in subjects screened for stage 1 HT.
机译:背景:本研究的目的是研究在1级HT筛查的年轻患者队列中,AGTR1的A1166C多态性和AGTR2的-1332G / A多态性对持续性高血压(HT)和代谢综合征的发生率的影响。方法:我们评估了420名从未接受过HT治疗的白人高血压受试者,并在HT和门诊记录性威尼斯研究(HARVEST)中随访了7.3年。突发事件的医生诊断为HT,动态血压升高(BP)和新发代谢综合征。结果:对于AGTR1,AA基因型组中37.2%的患者,AC基因型组中47.5%的患者和CC基因型组中66.7%的患者在随访期间出现了HT(P = 0.001)。 CC基因型患者的动态收缩压(P = 0.007)和舒张压(P <0.001)明显高于其余组。在CC患者中,随访期间新发的代谢综合征(n = 30,P = 0.008)和随访结束时代谢综合征的发生频率(n = 65,P = 0.002)也更为常见。和AC基因型。在Cox分析中,具有CC基因型的受试者发生HT(危险比(HR)1.6、95%置信区间(CI)1.2-2.0,P = 0.000)和代谢综合征(HR 2.8、1.5-5.2, P = 0.002)。在AGTR2多态性与任何结果指标之间未发现关联。结论:AGTR1 A1166C基因多态性可被认为是遗传标记,在筛选1期HT的受试者中,其可能导致BP升高和代谢综合征的发展。

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