Preparation of Ginkgolide B Polybutylcyanoacrylate Nanoparticles Suspension Powder-Injection

摘要

Ginkgolide B polybutylcyanoacrylate nanoparticles suspension suspension were prepared using polybutylcyanoacrylate as drug carrier by interface polycondensation method and the trehalose was selected as cryoproctant in forming the powder injection. The result showed that the encapsulation efficiency and the drug loading of the drug nanoparticles suspension were 96.74 ± 1.25 % and 5.74 ± 0.46 % respectively and the powder injection of the ginkgolide B polybutylcyanoacrylate nanoparticles suspension exhibited good appearance, re-dispersion and high stability at the room temperature. The high loading of ginkgolide B polybutylcyanoacrylate in nanoparticles suspension might successfully solve the insolubility of ginkgolide B in aqua solution and be possible used as a brain targeted candidate drug form.