THE PREPARATION METHOD OF DOXORUBICIN-POLYBUTYLCYANOACRYLATE NANOPARTICLES

摘要

A preparation method of doxorubicin-polybutylcyanoacrylate nanoparticles, whose steps are as follows: HCl solution react with doxorubicin hydrochloride powders, and stir the mixture to dissolve, followed by the addition of Dextran70, then a-butylcyanoacrylate, stir it till an orange opalescence appears, then adjust pH to 7; filter it over filter membrane of 0.45µm, and dry to give the nanoparticles. The DOX­PBCA-NP available from the invention can carry many drug including chemotherapeutics and gene drug, whose targeting property can significantly reduce the toxicity of drug, improve the therapeutic effect, reduce dose anddose frequency, improve patient compliance, increase the stability of gene drug against ribozyme, increase the drug concentration in cells and increase the action time.