Visible-Light-Induced Radical Tandem Aryldifluoroacetylation of Cinnamamides: Access to Difluoroacetylated Quinolone-2-ones And 1-Azaspiro[4.5]decanes

摘要

A visible light-mediated difluoroacetylation of cinnamamides with ethyl bromodifluoroacetate as a CF2 radical precursor is described. The reaction incorporates tandem cyclization or cyclization/dearomatization processes. The latter process occurs when there is a p-RO substituent on the aniline. This protocol affords straightforward new routes to separately synthesize quinoline-2-ones and spiro[4.5]decanes in moderate to good yields.