首页> 外文期刊>Anticancer Research: International Journal of Cancer Research and Treatment >Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans.
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Protective effect of Cox-2 allelic variants on risk of colorectal adenoma development in African Americans.

机译:Cox-2等位基因变体对非洲裔美国人大肠腺瘤发生风险的保护作用。

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摘要

BACKGROUND: Recent evidence indicates that single nucleotide polymorphisms (SNPs) in the Cox-2 gene may modulate the risk of colorectal adenoma development. PATIENTS AND METHODS: We explored possible associations between Cox-2 polymorphisms and risk of adenoma development in an African American case-control study comprising 72 cases of advanced adenomas and 146 polyp-free controls. An exhaustive approach of genotyping 13 haplotype-tagging SNPs (ht SNPs) distributed over the entire COX-2 gene was used. RESULTS: Statistically significant inverse associations were observed between the heterozygous genotypes at the 5229 G>T polymorphism in intron 5 [odds ratio (OR)=0.42; confidence interval (CI)=0.19-0.92; p=0.03] and at the 10935 A>G polymorphism in the 3' flanking region downstream from the poly A signals (OR=0.39; CI=0.18-0.83;p=0.01) and the risk for colorectal adenoma development. CONCLUSION: The data from our pilot study suggest that allelic variants of the COX-2 gene significantly influence the risk of adenoma development in the African American population.
机译:背景:最近的证据表明,Cox-2基因中的单核苷酸多态性(SNP)可能会调节结直肠腺瘤发展的风险。患者和方法:我们在一项包括72例晚期腺瘤和146例无息肉对照的非裔美国人病例对照研究中,探讨了Cox-2基因多态性与腺瘤发生风险之间的可能联系。使用了详尽的基因分型方法,将13个单倍型标记SNP(ht SNP)分布在整个COX-2基因上。结果:内含子5的5229 G> T多态性在杂合子基因型之间观察到统计学上显着的负相关[奇数比(OR)= 0.42;置信区间(CI)= 0.19-0.92; p = 0.03],并且在polyA信号下游的3'侧翼区域的10935 A> G多态性处(OR = 0.39; CI = 0.18-0.83; p = 0.01)以及发生结直肠腺瘤的风险。结论:我们的初步研究数据表明,COX-2基因的等位基因变异显着影响非裔美国人人群腺瘤发展的风险。

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