METHODS FOR DIAGNOSIS OR DETECT colorectal adenomas ADVANCED AND NEOPLASMS COLORECTAL IN A SUBJECT HUMAN, BIOMARKERS OR biosignatures FOR colorectal adenomas ADVANCED AND NEOPLASMS COLORECTAL, KITS FOR DIAGNOSTIC colorectal adenomas ADVANCED AND USE adenomas RISK DIAGNOSIS colorectal ADVANCED AND / OR NEOPLASM COLORECTAL AND USE OF THE KIT

摘要

“Methods for diagnosing or detecting advanced colorectal adenomas and colorectal neoplasia in a human subject, biomarkers or biosignatures for advanced colorectal adenomas and colorectal neoplasia, kits for diagnosing advanced colorectal adenomas or colorectal adenomas / risk The present invention relates generally to the field of colorectal cancer detection, and more particularly, to plasma microrna for the detection of early colorectal cancer. Specifically, the present invention includes methods, kits and biomarkers for diagnosing or detecting colorectal neoplasia in a human subject comprising the steps of: a method for diagnosing or detecting colorectal neoplasia in a human subject comprising the steps of: obtaining one or more samples of the subject suspected of suffering from colorectal neoplasia; measuring an overall expression level or pattern of one or more microwaves obtained from one or more biological samples from the subject; and comparing the global expression pattern of one or more microrna of the biological sample of the subject suspected of having colorectal neoplasia with the global expression pattern of one or more microrna of a biological sample of a normal subject, where the normal subject is a healthy subject who does not suffer from colorectal neoplasia, where overexpression of a combination of mir19a and mir19b, or mir19a and mir19b and mir15b is indicative of colorectal cancer.