Dissolution is an ever-evolving test with the development of novel dosage forms and increased quality expectations from regulators. There are many "hot topics" in dissolution testing, but probably the most pressing is the need for clinically relevant dissolution specifications and the methodology needed to achieve this goal. Other hot topics are in vitro release methods for the many special dosage forms; USP initiatives and general chapters on items such as semi solid dosage forms, gelatin capsules, two-tier testing with enzyme addition to media, chewable tablets, validation and method development; and the Apparatus 1 and 2 performance verification test.
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