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The association between anxiety, traumatic stress, and obsessive–compulsive disorders and chronic inflammation: A systematic review and meta‐analysis

机译：焦虑，创伤应激和强迫性疾病与慢性炎症之间的关联：系统评价和荟萃分析

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Background >Anxiety is characterized by prolonged preparation for real or perceived threat. This may manifest both as psychological and physiological activation, ultimately leading to greater risk for poor health. Chronic inflammation may play an integral role in this relationship, given the influential role that it has in chronic illness. The aim of this meta‐analysis is to examine levels of chronic inflammation, measured by inflammatory cytokines and C‐reactive protein, in people with anxiety disorders, PTSD (posttraumatic stress disorder), or obsessive–compulsive disorder compared to healthy controls. Several moderating variables, including specific diagnosis and depression comorbidity, were also assessed. </section> <section xml:id="da22790-sec-0020"> <title type="main">Methods >Seventy six full‐text articles were screened for eligibility with 41 studies ultimately included in analysis. </section> <section xml:id="da22790-sec-0030"> <title type="main">Results > Results demonstrated a significant overall difference between healthy controls (HCs) and people with anxiety disorders in pro‐inflammatory cytokines ( P ?=?0.013, Hedge's g ?=?–0.39), which appears to be largely driven by interleukin‐1β (IL‐1β; P ?=?0.009, Hedge's g ?=?–0.50), IL‐6 ( P ?<?0.001, Hedge's g ?=?–0.93), and tumor necrosis factor‐α ( P ?=?0.030, Hedge's g ?=?–0.56). Moderation analyses revealed a moderating effect of diagnosis ( P ?=?0.050), as only individuals with PTSD demonstrated differences </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> <div class="translation abstracttxt"> <span class="zhankaihshouqi fivelineshidden" id="abstract"> <span>机译：</span><Abstract Type =“Main”XML：Lang =“en”> <第XML：ID =“da22790-ec-0010”> <标题类型=“main”>背景</ title> >焦虑以延长为特征准备真实或感知威胁。这可能表现为心理和生理活化，最终导致健康状况差的风险更大。鉴于它在慢性疾病中的有影响力的作用，慢性炎症可能在这种关系中发挥积分作用。该荟萃分析的目的是检查焦虑症，受焦虑症和C反应蛋白的慢性炎症的水平，与健康对照相比，受焦虑症，PTSD（术后应激障碍）或强迫症的患者。还评估了几种调节变量，包括特异性诊断和抑郁症合并症。</ p> </ section> <secto XML：ID =“DA22790-SEC-0020”> <标题类型=“main”>方法</ title>筛选七十六个全文文章，用于有41项研究最终包括在分析中的资格。</ p> </ section> <section XML：ID =“da22790-ex-0030”> <标题类型=“main” >结果</标题> >结果表明，健康对照（HCS）和患有促炎细胞因子中焦虑症的人之间的显着差异（ p </ i>？=？0.013，对冲的 g </ i>？=Δ - 0.39），似乎在很大程度上由白细胞介素-1β（IL-1β; P </ i>？= 0.009，对冲的 g </ i>？= ？-0.50），IL-6（ P </ I>？<0.001，对冲的 g </ i>？=？ - 0.93）和肿瘤坏死因子-α（ p </ i>？= 0.030，对冲的 g </ i>？=？ - 0.56）。适度分析显示诊断的调节效果（ P </ i>？= 0.050），因为只有具有PTSD的个体表现出差异 </span> <span class="z_kbtn z_kbtnclass hoverxs" style="display: none;">展开▼</span> </div> </div> <div class="record"> <h2 class="all_title" id="enpatent33" >著录项</h2> <ul> <li> <span class="lefttit">来源</span> <div style="width: 86%;vertical-align: text-top;display: inline-block;"> <a href='/journal-foreign-32884/'>《Depression and anxiety》</a> <b style="margin: 0 2px;">|</b><span>2018年第11期</span><b style="margin: 0 2px;">|</b><span>共14页</span> </div> </li> <li> <div class="author"> <span class="lefttit">作者</span> <p id="fAuthorthree" class="threelineshidden zhankaihshouqi"> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Renna Megan E.&option=202" target="_blank" rel="nofollow">Renna Megan E.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OToole Mia S.&option=202" target="_blank" rel="nofollow">OToole Mia S.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Spaeth Phillip E.&option=202" target="_blank" rel="nofollow">Spaeth Phillip E.;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Lekander Mats&option=202" target="_blank" rel="nofollow">Lekander Mats;</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Mennin Douglas S.&option=202" target="_blank" rel="nofollow">Mennin Douglas S.;</a> </p> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zkzz" style="display: none;">展开▼</span> </div> </li> <li> <div style="display: flex;"> <span class="lefttit">作者单位</span> <div style="position: relative;margin-left: 3px;max-width: 639px;"> <div class="threelineshidden zhankaihshouqi" id="fOrgthree"> <p>Counseling and Clinical PsychologyTeachers College Columbia UniversityNew York New York;</p> <p>Aarhus UniversityAarhus Denmark;</p> <p>Counseling and Clinical PsychologyTeachers College Columbia UniversityNew York New York;</p> <p>Department of Clinical NeuroscienceKarolinska InstitutetSolna Sweden;</p> <p>Counseling and Clinical PsychologyTeachers College Columbia UniversityNew York New York;</p> </div> <span class="z_kbtnclass z_kbtnclassall hoverxs" id="zhdw" style="display: none;">展开▼</span> </div> </div> </li> <li > <span class="lefttit">收录信息</span> <span style="width: 86%;vertical-align: text-top;display: inline-block;"></span> </li> <li> <span class="lefttit">原文格式</span> <span>PDF</span> </li> <li> <span class="lefttit">正文语种</span> <span>eng</span> </li> <li> <span class="lefttit">中图分类</span> <span>R749.72; </span> </li> <li class="antistop"> <span class="lefttit">关键词</span> <p style="width: 86%;vertical-align: text-top;"> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=anxiety disorders&option=203" rel="nofollow">anxiety disorders;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=biological markers&option=203" rel="nofollow">biological markers;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=OCD&option=203" rel="nofollow">OCD;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=PTSD&option=203" rel="nofollow">PTSD;</a> <a style="color: #3E7FEB;" href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=SAD&option=203" rel="nofollow">SAD;</a> </p> <div class="translation"> 机译：焦虑症;生物标志;强迫症;悲伤;悲伤; </div> </li> </ul> </div> </div> <div class="literature cardcommon"> <div class="similarity "> <h3 class="all_title" id="enpatent66">相似文献</h3> <div class="similaritytab clearfix"> <ul> <li class="active" >外文文献</li> <li >中文文献</li> <li >专利</li> </ul> </div> <div class="similarity_details"> <ul > <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/journal-foreign-detail/0704025195517.html">The association between anxiety, traumatic stress, and obsessive–compulsive disorders and chronic inflammation: A systematic review and meta‐analysis</a> 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</b><a class="enjiyixqcontent" href="/academic-conference-cn_meeting-6949_thesis/020221791794.html">人群膳食叶酸水平对MTHFR基因型、同型半胱氨酸与卒中风险之间关联效应的修饰作用：一项遗传学与随机双盲临床研究的荟萃分析</a> <b>[C]</b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Michael V Holmes&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . Michael V Holmes</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Paul Newcombe&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Paul Newcombe</a> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=Jaroslav A Hubacek&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor">,Jaroslav A Hubacek</a> <span> <a href="/conference-cn-6949/" target="_blank" rel="nofollow" class="tuijian_authcolor"> . 北京大学转化医学论坛暨中国动脉粥样硬化前沿论坛2012 </a> <span> <span> . 2012</span> </span> </div> </li> <li> <div> <b>7. </b><a class="enjiyixqcontent" href="/academic-degree-domestic_mphd_thesis/020314099822.html">良性疾病全子宫切除术微创术式比较的系统评价和荟萃分析</a> <b>[A] </b> <span> <a href="/search.html?doctypes=4_5_6_1-0_4-0_1_2_3_7_9&sertext=黄志华&option=202" target="_blank" rel="nofollow" class="tuijian_auth tuijian_authcolor"> . 黄志华</a> <span> . 2009</span> </span> </div> </li> </ul> <ul style="display: none;"> <li> <div> <b>1. </b><a class="enjiyixqcontent" href="/patent-detail/06120113579182.html">用于预防和/或治疗慢性炎症性疾病和/或炎症性胃肠疾病和/或癌症的克里斯滕森菌科细菌</a> <b>[P]</b> . <span> 中国专利： CN113631174A </span> <span> . 2021-11-09</span> </div> </li> <li> <div> <b>2. </b><a class="enjiyixqcontent" href="/patent-detail/06120110126123.html">质子泵抑制剂在制备降低肺部炎症及治疗急性、慢性气道炎症性疾病的药物中的应用</a> <b>[P]</b> . <span> 中国专利： CN107648610A </span> <span> . 2018-02-02</span> </div> </li> <li> <div> <b>3. </b><a class="enjiyixqcontent" href="/patent-detail/06130422983980.html">compound, pharmaceutical composition; use of the compound for the manufacture of a medicament for treating irritable bowel syndrome, treating pain or painful syndromes, treating urinary incontinence, treating depression, fibromyalgia, anxiety, panic disorder, agorophobia, pre-traumatic stress disorder, pre-dysphoric disorder menstrual disorder, attention deficit disorder, obsessive compulsive disorder, social anxiety disorder, generalized anxiety disorder, autism, schizophrenia, obesity, anorexia nervosa, bulimia nervosa, gilles de la tourette syndrome, vasomotor discharge, cocaine addiction, sexual dysfunction, personality threshold disorder, fibromyalgia syndrome, diabetic neuropathic pain, chronic fatigue syndrome, shy drager syndrome, raynaud syndrome, parkinson's disease, and epilepsy, method of preparing a compound of structure (a), and Method of preparing a compound of structure (b)</a> <b>[P]</b> . <span> 外国专利：  BRPI0613031A2 </span> <span> . 2012-01-03</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：化合物，药物组合物;该化合物在制备用于治疗肠易激综合症，治疗疼痛或疼痛综合症，治疗尿失禁，治疗抑郁症，纤维肌痛，焦虑症，恐慌症，广场恐惧症，创伤前应激障碍，烦躁不安症，月经失调的药物中的用途，注意力缺陷障碍，强迫症，社交焦虑症，广泛性焦虑症，自闭症，精神分裂症，肥胖症，神经性厌食症，神经性贪食症，抽动秽语综合征，血管舒缩放电，可卡因成瘾，性功能障碍，人格阈障碍，纤维肌痛综合征，糖尿病性神经性疼痛，慢性疲劳综合症，害羞药物综合征，雷诺氏综合症，帕金森氏病和癫痫病，结构式（a）的化合物的制备方法和结构式（b）的化合物的制备方法 </span> </p> </li> <li> <div> <b>4. </b><a class="enjiyixqcontent" href="/patent-detail/06130417704180.html">Pharmaceutical composition comprising 3 alpha-hydroxy-3-beta methoxymethyl- 21-(1'-imidazolyl)-5-pregnan-20-one for use in the treatment of obsessive compulsive disorder, post-traumatic stress disorder or social anxiety disorder</a> <b>[P]</b> . <span> 外国专利：  IL211114A </span> <span> . 2014-04-30</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：包含3α-羟基-3-β甲氧基甲基-21-（1'-咪唑基）-5-pregnan-20-one的药物组合物，用于治疗强迫症，创伤后应激障碍或社交焦虑症 </span> </p> </li> <li> <div> <b>5. </b><a class="enjiyixqcontent" href="/patent-detail/06130422974129.html">A compound of thiazole or one of its salts used to treat and/or prevent selective anxiety disorders, including Panic Disease, Agoraphobia, obsessive-compulsive disorder, social phobia, post-traumatic stress disorder, and special phobia.</a> <b>[P]</b> . <span> 外国专利：  CL2012000533A1 </span> <span> . 2012-09-14</span> </div> <p class="zwjiyix translation" style="max-width: initial;height: auto;word-break: break-all;white-space: initial;text-overflow: initial;overflow: initial;"> <span>机译：噻唑的化合物或其盐之一，用于治疗和/或预防选择性焦虑症，包括恐慌症，恐惧症，强迫症，社交恐惧症，创伤后应激障碍和特殊恐惧症。 </span> </p> </li> </ul> </div> </div> </div> <div class="theme cardcommon" style="overflow: auto;display:none"> <h3 class="all_title" id="enpatent55">相关主题</h3> <ul id="subject"> </ul> </div> </div> </div> </div> <div class="right rightcon"> <div class="details_img cardcommon clearfix" style="margin-bottom: 10px;display:none;" > </div> </div> </div> <div id="thesis_get_original1" class="downloadBth" style="bottom: 19px;z-index: 999;" onclick="ywcd('0704025195517','4',7,2,1,'',this,24)" class="delivery" prompt="010401" title="通过人工服务将文献原文发送至邮箱" >获取原文</div> <div class="journalsub-pop-up" style="display: none"> <div class="journal-sub"> <h2>期刊订阅</h2> <img src="https://cdn.zhangqiaokeyan.com/img/loginclose.png" alt="" 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