Fast and Straightforward Method for the Quantification of Pazopanib in Human Plasma Using LC-MS/MS

Verheijen Remy B.; Thijssen Bas; Rosing Hilde; Schellens Jan H. M.; Nan Lianda; Venekamp Nikkie; Beijnen Jos H.; Steeghs Neeltje; Huitema Alwin D. R.

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Fast and Straightforward Method for the Quantification of Pazopanib in Human Plasma Using LC-MS/MS

机译：使用LC-MS / MS在人血浆中定量Pazopanib的快速和直接方法

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Background: Pazopanib is an angiogenesis inhibitor approved for renal cell carcinoma and soft-tissue sarcoma. Studies indicate that treatment with pazopanib could be optimized by adapting the dose based on measured pazopanib plasma concentrations.

机译：背景：Pazopanib是血管生成抑制剂，用于肾细胞癌和软组织肉瘤。研究表明，通过基于测量的pazopanib血浆浓度调整剂量，可以优化与pazopanib的处理。

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来源
《Therapeutic Drug Monitoring》 |2018年第2期|共7页
作者
Verheijen Remy B.; Thijssen Bas; Rosing Hilde; Schellens Jan H. M.; Nan Lianda; Venekamp Nikkie; Beijnen Jos H.; Steeghs Neeltje; Huitema Alwin D. R.;
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作者单位

Netherlands Canc Inst Antoni van Leeuwenhoek Dept Pharm &

Pharmacol Plesmanlaan 121 NL-1066 CX;

Netherlands Canc Inst Antoni van Leeuwenhoek Dept Pharm &

Pharmacol Plesmanlaan 121 NL-1066 CX;

Netherlands Canc Inst Antoni van Leeuwenhoek Dept Pharm &

Pharmacol Plesmanlaan 121 NL-1066 CX;

Netherlands Canc Inst Antoni van Leeuwenhoek Dept Med Oncol &

Clin Pharmacol Amsterdam;

Netherlands Canc Inst Antoni van Leeuwenhoek Dept Pharm &

Pharmacol Plesmanlaan 121 NL-1066 CX;

Netherlands Canc Inst Antoni van Leeuwenhoek Dept Pharm &

Pharmacol Plesmanlaan 121 NL-1066 CX;

Netherlands Canc Inst Antoni van Leeuwenhoek Dept Pharm &

Pharmacol Plesmanlaan 121 NL-1066 CX;

Netherlands Canc Inst Antoni van Leeuwenhoek Dept Med Oncol &

Clin Pharmacol Amsterdam;

Univ Utrecht Med Ctr Dept Clin Pharm Utrecht Netherlands;

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原文格式 PDF
正文语种 eng
中图分类生药学（天然药物学）;
关键词
pazopanib; LC-MS/MS; pharmacokinetics; therapeutic drug monitoring; bioanalytical methods;

机译：Pazopanib;LC-MS / MS;药代动力学;治疗药物监测;生物分析方法;

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专利

1. Fast and Straightforward Method for the Quantification of Pazopanib in Human Plasma Using LC-MS/MS [J] . Verheijen Remy B., Thijssen Bas, Rosing Hilde, Therapeutic Drug Monitoring . 2018,第2期

机译：使用LC-MS / MS在人血浆中定量Pazopanib的快速和直接方法
2. Overestimation of 25-hydroxyvitamin D3 by increased ionisation efficiency of 3-epi-25-hydroxyvitamin D3 in LC-MS/MS methods not separating both metabolites as determined by an LC-MS/MS method for separate quantification of 25-hydroxyvitamin D3, 3-epi-25-hydroxyvitamin D3 and 25-hydroxyvitamin D2 in human serum [J] . Johannes M.W. van den Ouweland, Antonius M. Beijers, Henny van Daal Journal of chromatography, B. Analytical technologies in the biomedical and life sciences . 2014,第Null期

机译：在LC-MS / MS方法中不能通过分离3-Epi-25-羟基维生素D3的电离效率提高对25-羟基维生素D3的高估，如通过LC-MS / MS方法对25-羟基维生素D3、3进行单独定量所确定的那样人血清中的-epi-25-羟基维生素D3和25-羟基维生素D2
3. Quantification of seven apolipoproteins in human plasma by proteotypic peptides using fast LC-MS/MS [J] . Proteomics. Clinical applications . 2013,第11a12期

机译：使用快速LC-MS / MS的蛋白质肽定量蛋白质蛋白血浆中的七个载脂蛋白
4. Development and Qualification of a Fast and Sensitive LC-MS/MS Method for the Simultaneous Quantification of Microdosed Statins in Human Plasma [C] . CM Chavez-Eng, RW Lutz, D Goykhman, ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：快速敏感LC-MS / MS方法的开发和鉴定，用于同时定量人血浆中微型毒素的微量定量
5. Development of Methods for the Analysis of Human Protamine Via 2D LC-MS/MS [D] . Samuel, Jacob Matthew 2018

机译：通过2D LC-MS / MS分析人鱼精蛋白的方法开发
6. Fast and Simple LC-MS/MS Method for Rifampicin Quantification in Human Plasma [O] . Žane Temova Rakuša, Robert Roškar, Anita Klančar Andrejc, 1952

机译：快速，简单的LC-MS / MS法测定人血浆中的利福平
7. Simple, fast and robust LC-MS/MS method for the simultaneous quantification of canagliflozin, dapagliflozin and empagliflozin in human plasma and urine [O] . Annemarie B. van der Aart-van der Beek, A. Mireille A. Wessels, Hiddo J.L. Heerspink, 2020

机译：用于同时定量甲烷醇素，Dapagliflozin和Empagliflozin的简单，快速且坚固的LC-MS / MS方法，在人血浆和尿液中

Fast and Straightforward Method for the Quantification of Pazopanib in Human Plasma Using LC-MS/MS

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