Lymphocyte subsets in primary immune thrombocytopenia

摘要

The aim of this study was to explore the clinical significance of T-lymphocyte subsets in the peripheral blood of patients with adult primary immune thrombocytopenia (ITP) in an active phase. T-lymphocyte subsets in the peripheral blood of 90 ITP patients in the active phase and 59 normal controls were detected by flow cytometry. ITP patients were treated with a conventional dose of corticosteroids, and therapeutic response was evaluated after 3 months. The level of CD4(+) T lymphocytes (35.7 +/- 4.6%) and natural killer cells (13.1 +/- 2.1%) in the active ITP patients was lower compared with the control group (40.4 +/- 3.7% and 23.2 +/- 1.1%, respectively, P<0.05 for both). The level of CD8(+) T lymphocytes (30.11 +/- 4.50%) in ITP showed a significantly wider distribution than that in the normal controls (25.5 +/- 5.91%, P<0.05). Additionally, the patients with higher levels of CD4(+) T cells were less likely to respond to corticosteroids (r=69, P=0.04). The detection of immunocyte subsets might be helpful for the ITP patients concerning their diagnosis and determination of therapeutic outcome. Blood Coagul Fibrinolysis 25: 816-819 (C) 2014 Wolters Kluwer Health vertical bar Lippincott Williams & Wilkins.